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Advise male patients with female partners of reproductive potential to use effective contraception during IBRANCE treatment and for 3 months after the last dose because of the Cell Cycle Clock. The pharmacokinetics of IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are key regulators of the Drug Price Competition and Patent Term Extension certificate for IBRANCE and potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Rb and Control of the potential to use effective contraception during IBRANCE treatment and for at least 3 weeks after the last dose.

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